Oral Lipid-Based Formulations: Enhancing the Bioavailability of Poorly Water-Soluble Drugs

By

David J. Hauss, Bristol-Myers Squibb Company , Princeton, New Jersey, USA

Description

Oral lipid-based formulations are attracting considerable attention due to their capacity to facilitate gastrointestinal absorption and reduce or eliminate the effect of food on the absorption of poorly water-soluble, lipophilic drugs. Despite the obvious and demonstrated utility of these formulations for addressing a persistent and growing problem of major significance, the pharmaceutical industry has been slow to apply and further develop this technology. This title provides a comprehensive summary of the theoretical and practical aspects of oral lipid-based formulations for use in industry, and provides further insights into a developing technology expected to assume increasing prominence in years to come.

Key Features

  • Provides a detailed review of currently marketed drug products formulated with lipids and an in-depth review of the excipients used to prepare these formulations
  • Details the sequential stages of lipid-based formulation development, beginning with feasibility assessment and prototype formulation development and concluding with product scale-up and manufacturing considerations
  • Describes the development and characterization of liquid, semi-solid, and self-emulsifying formulations
  • Reviews the physiology of gastrointestinal lipid absorption-an important point for understanding the mechanisms by which lipid-based formulations enhance drug bioavailability
  • Includes case studies detailing the development of oral lipid-based formulations within a major pharmaceutical company

Book details

  • Publisher: CRC Press; 1 edition (June 8, 2007)
  • Language: English
  • ISBN-10: 0824729455
  • ISBN-13: 978-0824729455

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