Pharmacokinetics and Metabolism in Drug Design, 3rd Edition

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Description

In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties. Although the previous chapter layout has been retained, substantial revisions have been made, with new topics such as pro-drugs, active metabolites and transporters covered in detail in a manner useful to the Drug Discovery scientist. The authors discuss the parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts.

While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects. Uniquely comprehensive, the book relates physicochemistry and chemical structure to pharmacokinetic properties and ultimately drug efficacy and safety.

New to This Edition

  • In the Physicochemistry chapter, new sections on membrane systems and on the BCS classification have been added
  • The Absorption chapter now also discusses active transports and prodrugs for increased oral absorption.
  • Distribution of drugs into tumors and active metabolites are now discussed in chapters 4 and 5.
  • Features several new subchapters on novel approaches that are currently in the focus of pharmaceutical scientists.
  • as been completely rewritten to cover the current risk assessment-driven approach in the field.
  • Chapter 9 (Inter-species scaling) has been replaced with a new chapter on the prediction of human pharmacokinetics that shows the current integrated in vitro/in vivo/in silico approach that has become the standard in the industry.
  • Data in figures and tables have been updated where appropriate, and new references have been added.

Book details

  • Publisher: Wiley-VCH; 3 edition (May 2012)
  • Language: English

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