Aulton’s Pharmaceutics 4th Edition, The Design and Manufacture of Medicines

By  Michael E. Aulton BPharm PhD FAAPS MRPharmS , Kevin M.G. Taylor BPharm PhD FAAPS FRPharmS

Pharmaceutics is one of the most diverse subject areas in all of pharmaceutical science. In brief, Aulton’s Pharmaceutics 4th Edition is concerned with the scientific and technological aspects of the design and manufacture of dosage forms or medicines. An understanding of pharmaceutics is therefore vital for all pharmacists and those pharmaceutical scientists who are involved with converting a drug or a potential drug into a medicine that can be delivered safely, effectively and conveniently to the patient.

Now in the fourth edition of Aulton’s Pharmaceutics, this best-selling textbook in pharmaceutics has been brought completely up to date to reflect the rapid advances in delivery methodologies by eye and injection, advances in drug formulations and delivery methods for special groups (such as children and the elderly), nanomedicine, and pharmacognosy. At the same time the editors have striven to maintain the accessibility of the text for students of pharmacy, preserving the balance between being a suitably pitched introductory text and a clear reflection of the state of the art.

Aulton’s Pharmaceutics 4th Edition is on most reading lists for a UK Pharmacy Degree (MPharm). It is great for the Pharmaceutics aspect of the course. It is easy to read, with good diagrams and pictures to help explain concepts well. It is probably one of the easiest reads for Pharmaceutics textbooks. It is also helpful when writing lab reports and assignments and is a good reference source.

Key Features

  • provides a logical, comprehensive account of drug design and manufacture
  • includes the science of formulation and drug delivery
  • designed and written for newcomers to the design of dosage forms


What is ‘pharmaceutics’?

1. Design of dosage forms

PART 1: Scientific principles of dosage form design

2. Dissolution and solubility | 3. Properties of solutions | 4. Surfaces and interfaces | 5. Disperse systems | 6. Rheology | 7. Kinetics

PART 2: Particle science and powder technology

8. Solid-state properties | 9. Particle size analysis | 10. Particle size reduction and size separation | 11. Mixing | 12. Powder flow

PART 3: Pharmaceutical microbiology and sterilization

13. Fundamentals of microbiology | 14. Pharmaceutical applications of microbiological techniques | 15. Action of physical and chemical agents on microorganisms | 16. Principles of sterilization | 17. Sterilization in practice

PART 4: Biopharmaceutical principles of drug delivery

18. Introduction to biopharmaceutics | 19. Gastrointestinal tract – physiology and drug absorption | 20. Bioavailability – physicochemical and dosage form factors | 21. Assessment of biopharmaceutical properties | 22. Dosage regimens

PART 5: Dosage form design and manufacture

23. Pharmaceutical preformulation | 24. Solutions | 25. Clarification | 26. Suspensions | 27. Emulsions and Creams | 28. Powders, granules and granulation  | 29. Drying | 30. Tablets and compaction | 31. Modified-release oral drug delivery  | 32. Coating of tablets and multiparticulates | 33. Hard capsules | 34. Soft capsules | 35 Dissolution testing of solid dosage forms | 36 Parenteral drug delivery | 37. Pulmonary drug delivery | 38. Nasal drug delivery | 39. Topical and transdermal drug delivery  | 40. Wound dressings | 41. Ocular drug delivery | 42. Rectal and vaginal drug delivery | 43. Design and administration of medicines for children and the elderly  | 44. The formulation and manufacture of plant medicines  | 45. Pharmaceutical nanotechnology and nanomedicines | 46. Delivery of biopharmaceuticals


47. Packaging  | 48. Chemical stability in dosage forms  | 49. Product stability and stability testing | 50. Microbial contamination, spoilage and preservation of medicines

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