Basic Pharmacokinetics Second edition

By Sunil S. Ph.D. Jambhekar, Philip J. Ph.D. Breen

Basic Pharmacokinetics second edition provides an understanding of the principles of pharmacokinetics and biopharmaceutics. It addresses clearly and concisely how these principles can be applied to achieve successful drug therapy. The applications of principles and equations are illustrated with related problem sets and problem solving exercises.

Features include:

  • the use of profiles (sketches of relationships among pharmacokinetic variables and parameters)
  • learning objectives
  • complete review of mathematical tools required to practice pharmacokinetics.

This new edition has been revised and updated to include:

  • new chapters on metabolite pharmacokinetics and pharmacokinetic data fitting
  • expanded question data base to include multiple choice questions and true/false questions
  • a large increase in the number of questions based on pharmacokinetic profiles.

This 2nd edition of Basic Pharmacokinetics is an invaluable textbook for undergraduate and graduate students in pharmacy, medicine, and the pharmaceutical sciences. It enables the reader to become adept at solving pharmacokinetic problems arising in drug therapy and to understand the applications and utility of equations in clinical practice.

Reviews

“The authors have done a great job of explaining basic pharmacokinetic principles and mathematical equations. The application of this material is not fully discussed in the book, as many of the problem sets are mathematically oriented rather than patient-based. This would be a good resource for entry-level PharmD students.”

The book covers general concepts in pharmacokinetics, such as various routes of administration, multicompartment models, and nonlinear kinetics. One chapter is devoted to drug interactions. The authors use multiple examples and analogies to help readers understand difficult concepts and equations. Helpful features include diagrams, a glossary of definitions, a glossary of abbreviations, and problem sets with answers in several chapters. Chapters devoted to specific drugs that are emphasized in the pharmacy curriculum (i.e. vancomycin, aminoglycosides, phenytoin, and amiodarone) would have enhanced the utility of this book. This material appears to be included in some chapters, but not fully explained in any one chapter. Another omission is pharmacokinetics in geriatric, pregnant, and pediatric patients. “

Content

1. Introduction and Overview

2. Mathematical Review

3. Intravenous Bolus Administration (One-compartment Model)

4. Clearance Concepts

Problem Set 1

5. Drug Absorption From the Gastrointestinal Tract

6. Extravascular Routes of Drug Administration

Problem Set 2

7. Bioavilability/bioequivalence

Problem Set 3

8. Factors Affecting Drug Absorption: Physicochemical Factors

9. Gastrointestinal Absorption: Role of the Dosage Form

10. Continuous Intravenous Infusion (One-compartment Model)

Problem Set 4

11. Multiple Dosing: Intravenous Bolus Administration

12. Multiple Dosing: Extravascular Routes of Drug Administration

Problem Set 5

13. Two-compartment Model

Problem Set 6

14. Multiple Intermittent Infusions

Problem Set 7

15. Nonlinear Pharmacokinetics

Problem Set 8

16. Drug Interactions

Problem Set 9

17. Pharmacokinetic and Pharmacodynamic Relationships

Problem Set 10

18. Metabolite Pharmacokinetics

19. Pharmacokinetic Data Fitting

20. Pharmacokinetics and Pharmacodynamics of Biotechnology Drugs

Appendix: Statistical Moment Theory in Pharmacokinetics

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